Targeted metabolomic profiling reveals inflammation–associated longitudinal changes in plasma metabolites following on-pump coronary bypass surgery
These results reveal pronounced changes in plasma metabolite populations after CABG, which likely result from the combined effects of surgical and post-operative stress, systemic inflammation, reduced dietary intake, and possibly changes in gut microflora.
Authors
- Jens Wippermann (ORCID: https://orcid.org/0000-0001-5998-118X)
- Sam Varghese (ORCID: https://orcid.org/0000-0002-1252-6611)
- George Awad (ORCID: https://orcid.org/0000-0002-4432-1733)
- Frank Pessler
- Fakhar H. Waqas
- Priya Veluswamy (ORCID: https://orcid.org/0000-0002-1702-2834)
- Sven Schuchardt (ORCID: https://orcid.org/0000-0002-4593-9324)
- Max Wacker (ORCID: https://orcid.org/0000-0003-0664-2613)
- Frieder Neu
Institutions
- Medizinische Hochschule Hannover (DE)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- Helmholtz Centre for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
- Center for Experimental and Clinical Infection Research (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fmed.2025.1673132
- Primary Topic
- Cardiac and Coronary Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00