Identification of novel lipid metabolism-related biomarkers of aortic dissection by integrating single-cell RNA sequencing analysis and machine learning algorithms
These findings suggest that PLIN2/PLIN3 could be key mediators of metabolic dysregulation and immune activation in aortic dissection, highlighting their potential as diagnostic markers and therapeutic targets.
Authors
- Yong‐Qiang Deng (ORCID: https://orcid.org/0000-0002-2306-1039)
- Zetong Zheng
- Qiang Zhao (ORCID: https://orcid.org/0000-0001-9017-663X)
- Jiashu Sun (ORCID: https://orcid.org/0000-0003-4255-6202)
- Zhechen Li
- Fei Xiao (ORCID: https://orcid.org/0000-0001-5262-2475)
- Gang Li (ORCID: https://orcid.org/0000-0002-3981-2239)
Institutions
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Institute of Water (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1681989
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00