Sex differences in Alzheimer’s disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals
Our results suggest that tailoring core AD CSF biomarkers by sex is not necessary for detecting Aβ PET positivity in CU individuals. However, sex differences in their association with Aβ deposition could influence their prognostic or monitoring applications.
Authors
- J Martínková (ORCID: https://orcid.org/0000-0002-7726-9847)
- Blanca Rodríguez‐Fernández (ORCID: https://orcid.org/0000-0002-5664-111X)
- Marta Milà‐Alomà (ORCID: https://orcid.org/0000-0002-5687-4597)
- Karine Fauria (ORCID: https://orcid.org/0000-0003-1506-4405)
- Annabella Beteta
- Alba Cañas (ORCID: https://orcid.org/0000-0001-5664-6941)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Armand González‐Escalante (ORCID: https://orcid.org/0000-0001-9456-5405)
- Albina Polo
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Sherezade Fuentes
- Anna Soteras (ORCID: https://orcid.org/0000-0001-6397-3430)
- Antonella Santuccione Chadha (ORCID: https://orcid.org/0000-0002-4021-3129)
- Wiesje Pelkmans (ORCID: https://orcid.org/0000-0002-6708-5374)
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- Sandra Pradas
- Davide Cirillo (ORCID: https://orcid.org/0000-0003-4982-4716)
- Paula Marne
- Raffaele Cacciaglia (ORCID: https://orcid.org/0000-0002-9216-949X)
- Jordi Huguet (ORCID: https://orcid.org/0000-0001-8420-4833)
- M. Florencia Iulita (ORCID: https://orcid.org/0000-0002-3360-4498)
- Marc Vilanova
- Laura L. Hernandez (ORCID: https://orcid.org/0000-0001-7591-5203)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Frances‐Catherine Quevenco (ORCID: https://orcid.org/0000-0003-1467-6880)
- Laura Castro‐Aldrete
- Annemarie Schumacher Dimech (ORCID: https://orcid.org/0000-0002-8016-5811)
- Maria Emilio
- Ruth Dominguez
- Ana Fernández‐Arcos
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Gwendlyn Kollmorgen
- Gema Huesa
- Laura Stankeviciute (ORCID: https://orcid.org/0000-0002-6601-3336)
- Patricia Genius (ORCID: https://orcid.org/0000-0003-1836-5123)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- Carol Van Hulle
- Carme Deulofeu
- Clara Quijano‐Rubio (ORCID: https://orcid.org/0000-0001-9050-3282)
- Mahnaz Shekari (ORCID: https://orcid.org/0000-0003-0531-8651)
- Sterling C. Johnson
- Maria Teresa Ferretti
- Natalia Vilor-Tejedor
- Margot Casals Brodú
Institutions
- Roche (Switzerland) (CH)
- University Health Network (CA)
- University of Wisconsin–Madison (US)
- University of Lucerne (CH)
- Universitat Pompeu Fabra (ES)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Charles University (CZ)
- Barcelona Supercomputing Center (ES)
- University of California System (US)
- Karolinska Institutet (SE)
- Roche Pharma AG (Germany) (DE)
- University Hospital in Motol (CZ)
- Pasqual Maragall Foundation (ES)
- Occupational Cancer Research Centre (CA)
- Karolinska Development (Sweden) (SE)
- Barcelonaβeta Brain Research Center (ES)
- Women's Brain Project (CH)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Global Brain Health Institute (US)
- Ontario Brain Institute (CA)
- Northern California Institute for Research and Education (US)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s13195-025-01844-1
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Alzheimer's Association
- European Commission
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- National Institute on Aging