Diabetes-associated differentially expressed genes as prognostic biomarkers and therapeutic targets in endometrial cancer: a comprehensive molecular analysis

In conclusion, our study establishes and validates a robust prognostic signature based on diabetes-related genes (DM-DEGs) for UCEC. This signature not only effectively stratifies patient risk but also delineates specific molecular pathways, such as those involving <i>SELENOP</i>, <i>CDKN2A</i>, and <i>PGR</i>, through which the diabetic milieu may drive tumor aggressiveness. These findings provide a mechanistic rationale for the diabetes-UCEC link and pave the way for developing personalized treatment strategies. Future work should focus on translating this signature into clinical practice and elucidating the precise biological roles of these DM-DEGs.