Dual oncogenic role of RNF220 in AML: linking metabolic rewiring to cell proliferation and immune evasion
NF220 acts as an oncogenic ubiquitin ligase in AML by coordinating dual pro-leukemic mechanisms: cell-intrinsic metabolic rewiring (glycolysis/phenylalanine) and immune evasion via microenvironment suppression. Targeting the FOXA1-RNF220 axis may offer novel therapeutic strategies for high-risk AML.
Authors
- Yao Xu (ORCID: https://orcid.org/0000-0002-2037-9105)
- Bixia Li (ORCID: https://orcid.org/0009-0008-1725-7618)
- Qitian Mu
- Jiang Shi (ORCID: https://orcid.org/0000-0002-6332-4569)
- Guifang Ouyang
- Xiao Yan
Institutions
- Ningbo Medical Center Lihuili Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fonc.2025.1670895
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00