Interrogation of the cellular hierarchies reveals neoplastic evolution and therapeutic vulnerability in craniopharyngioma
Our study reveals the neoplastic programming and evolution of craniopharyngioma at single cell and spatial levels. Notably, SASP-related FGF signaling is identified as a potential therapeutic target for ACP and inhibition of it reduces tumor cell proliferation in murine model.
Authors
- Zhidan Li (ORCID: https://orcid.org/0000-0002-7541-0157)
- Haotai Li
- Xixi Liu (ORCID: https://orcid.org/0000-0003-4440-5328)
- Zhongwen Xu (ORCID: https://orcid.org/0000-0002-9348-7262)
- Bin Zhang (ORCID: https://orcid.org/0000-0001-8835-8370)
- Yu Lu (ORCID: https://orcid.org/0009-0004-8398-1592)
- Liguo Zhang (ORCID: https://orcid.org/0009-0002-0730-6291)
- Yi Wen (ORCID: https://orcid.org/0000-0001-5599-1946)
- Hui Sheng
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4324-0835)
- Ying Huang (ORCID: https://orcid.org/0000-0001-9363-4034)
- Cuiqing Zhu (ORCID: https://orcid.org/0000-0002-9804-3126)
- Xuelian He (ORCID: https://orcid.org/0000-0001-8695-2667)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1093/neuonc/noaf249
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00