Microencapsulated Quercetin and <i>Bifidobacterium animalis</i> Independently Preserve Jejunal Enteric Neurons During Colorectal Carcinogenesis
This study provides the first evidence that colorectal carcinogenesis damages jejunal neurons. Treatments with microencapsulated quercetin or B. animalis independently preserved neuronal density and modulated gastrointestinal function. However, their combined administration did not enhance these effects, highlighting the need for further research into therapeutic interventions for preserving ENS integrity during colorectal carcinogenesis.
Authors
- José Ricardo de Arruda Miranda (ORCID: https://orcid.org/0000-0002-8306-8056)
- Erick Stoppa (ORCID: https://orcid.org/0000-0002-0903-6021)
- Jacqueline Nelisis Zanoni (ORCID: https://orcid.org/0000-0002-2892-5123)
- Lucas Casagrande (ORCID: https://orcid.org/0000-0001-5504-1676)
- Juliana Vanessa Colombo Martins Perles (ORCID: https://orcid.org/0000-0002-6701-2917)
- Waldiceu Aparecido Verri Jr (ORCID: https://orcid.org/0000-0003-2756-9283)
- Jean‐Pierre Timmermans (ORCID: https://orcid.org/0000-0003-2506-6252)
- Tânia Cristina Alexandrino Becker (ORCID: https://orcid.org/0000-0001-5952-6945)
- Carla Cristina de Oliveira Bernardo (ORCID: https://orcid.org/0000-0003-0581-791X)
- Mateus G. Godoy (ORCID: https://orcid.org/0000-0003-2209-7993)
- Sabrina Silva Sestak (ORCID: https://orcid.org/0000-0002-9988-412X)
- César Ferreira
- Maysa Pacheco Alvarez da Silva
Institutions
- Universidade Estadual de Maringá (BR)
- Universidade Estadual de Londrina (BR)
- University of Antwerp (BE)
- Antwerp Management School (BE)
- Entomological Society of Brazil (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1111/nmo.70190
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Universidade Estadual de Maringá