Hyaluronan-mediated motility receptor regulating the Wnt/β-catenin signaling resulting in hepatocellular carcinoma by inhibiting the phosphorylation activity of GSK-3β
HMMR stabilizes β-catenin by suppressing GSK-3β phosphorylation activity, which reduces β-catenin ubiquitination and degradation. Knocking down HMMR enhances GSK-3β expression and its degradative effect on β-catenin, thereby lowering β-catenin protein levels.
Authors
- Zongcai Yan
- Zhiming Zhang (ORCID: https://orcid.org/0000-0002-4472-7653)
- Yumei Zhang
- Xiuwen Wang (ORCID: https://orcid.org/0000-0001-6494-122X)
- Meiling He (ORCID: https://orcid.org/0009-0008-2121-3175)
Institutions
- Guangxi Medical University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s40001-025-03372-y
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00