An integrated analysis of three medulloblastoma clinical trials refines risk-stratification approaches for reducing toxicity and improving survival
Our integrated cross-trial analysis suggests toxicity can be reduced by eliminating disproportionate differences in therapy in favor of a more uniform treatment backbone. Moreover, we propose and model a risk-classification system that identifies the most appropriate cohorts on which to trial significant dose reductions in craniospinal irradiation or select treatment intensifications.
Authors
- Qian Li (ORCID: https://orcid.org/0000-0001-9874-3555)
- Roger J. Packer (ORCID: https://orcid.org/0000-0001-9413-7531)
- Karishma Gangwani (ORCID: https://orcid.org/0000-0002-2986-4481)
- Amy Smith (ORCID: https://orcid.org/0000-0002-9892-3203)
- Jeff M. Michalski (ORCID: https://orcid.org/0000-0003-0563-3766)
- Edgar Sioson (ORCID: https://orcid.org/0000-0002-7540-8516)
- Amar Gajjar (ORCID: https://orcid.org/0000-0001-5019-0699)
- Sarah Leary (ORCID: https://orcid.org/0000-0003-0225-6184)
- Paul A. Northcott (ORCID: https://orcid.org/0000-0002-1220-5252)
- Catherine A. Billups (ORCID: https://orcid.org/0000-0003-2819-4946)
- Congyu Lu (ORCID: https://orcid.org/0000-0003-2651-6251)
- Giles W Robinson (ORCID: https://orcid.org/0000-0001-7441-9486)
- James M. Olson (ORCID: https://orcid.org/0000-0001-5990-6534)
- Arzu Onar‐Thomas (ORCID: https://orcid.org/0000-0003-1005-2413)
- Sandeep Kumar Dhanda (ORCID: https://orcid.org/0000-0003-1381-7434)
- Maryam Fouladi (ORCID: https://orcid.org/0000-0002-5693-035X)
- Airen Zaldívar Peraza (ORCID: https://orcid.org/0009-0008-3234-2925)
- Tong Lin (ORCID: https://orcid.org/0000-0003-1181-3763)
- Yimei Li (ORCID: https://orcid.org/0000-0002-7046-4316)
- Xin Zhou (ORCID: https://orcid.org/0000-0003-3979-8200)
Institutions
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- University of Washington (US)
- Washington University in St. Louis (US)
- Fred Hutch Cancer Center (US)
- Children's Tumor Foundation (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1093/neuonc/noaf250
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Lebanese Syrian Associated Charities
- National Cancer Institute