Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology
This transcriptomic landscape serves as a resource for biomarker discovery, diagnostic refinement, and prediction of tumor biology and outcome. By enabling projection of new patients' bulk RNA-seq data onto the reference map using nearest neighbor analysis, the framework supports accurate subtype classification. The landscape is publicly available via Oncoscape, an interactive platform for global exploration and application.
Authors
- Taranjit S. Gujral (ORCID: https://orcid.org/0000-0002-4453-3031)
- Andrey Korshunov (ORCID: https://orcid.org/0000-0002-5257-3623)
- Srinidhi Varadharajan (ORCID: https://orcid.org/0000-0002-2033-0758)
- Philipp Sievers (ORCID: https://orcid.org/0000-0003-3237-6021)
- Stephen C. Mack (ORCID: https://orcid.org/0000-0001-9620-4742)
- Matt Jensen (ORCID: https://orcid.org/0000-0001-8617-9512)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Eric C. Holland (ORCID: https://orcid.org/0000-0002-3792-7120)
- Nicholas Nuechterlein (ORCID: https://orcid.org/0000-0002-9599-0865)
- Sonali Arora (ORCID: https://orcid.org/0000-0002-6661-3024)
- Michael D. Taylor (ORCID: https://orcid.org/0000-0001-7009-3466)
- Gregory Glatzer
Institutions
- St. Jude Children's Research Hospital (US)
- German Cancer Research Center (DE)
- Baylor College of Medicine (US)
- Heidelberg University (DE)
- University of Michigan (US)
- Texas Oncology (US)
- University Hospital Heidelberg (DE)
- Fred Hutch Cancer Center (US)
- Michigan Medicine (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1093/neuonc/noaf251
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00