A case series of adenomyoepithelioma of the breast with a case of malignant adenomyoepithelioma misinterpreted as polymorphous adenocarcinoma

This case series underscores the diagnostic challenges and importance of accurate differentiation between AME, MAME, and PmA, as misdiagnosis can significantly impact treatment and prognosis and highlighting the importance of IHC and molecular profiling. Given the potential for recurrence and metastasis, complete excision with negative margins remains the mainstay of treatment. This series contributes to the limited literature on these rare tumors, emphasizing the critical role of meticulous pathological evaluation and multidisciplinary approaches to improve patient outcomes.

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Publication Details

Journal
AME Case Reports
Published
2025-10-01
DOI
https://doi.org/10.21037/acr-24-178
Primary Topic
Breast Lesions and Carcinomas
Type
article
Field-Weighted Citation Impact
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article

A case series of adenomyoepithelioma of the breast with a case of malignant adenomyoepithelioma misinterpreted as polymorphous adenocarcinoma

Eli Avisar, Siarhei Melnikau, Christina Layton, Carmen Gómez et al.
AME Case Reports
Breast Lesions and Carcinomas
article

A case series of adenomyoepithelioma of the breast with a case of malignant adenomyoepithelioma misinterpreted as polymorphous adenocarcinoma

Eli Avisar, Siarhei Melnikau, Christina Layton, Carmen Gómez, Maria Paz De la Torre
article en

Abstract

This case series underscores the diagnostic challenges and importance of accurate differentiation between AME, MAME, and PmA, as misdiagnosis can significantly impact treatment and prognosis and highlighting the importance of IHC and molecular profiling. Given the potential for recurrence and metastasis, complete excision with negative margins remains the mainstay of treatment. This series contributes to the limited literature on these rare tumors, emphasizing the critical role of meticulous pathological evaluation and multidisciplinary approaches to improve patient outcomes.

AME Case ReportsVol. 9
University of Miami (US), Florida Atlantic University (US)
Openalex Percentile: Top 56%
Breast Lesions and Carcinomas
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