PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study

In patients with COVID-19-related ARDS patients, higher PEEP levels within the first 5 days after intubation were independently associated with AKI. These findings underscore the importance of ventilatory strategies to balance oxygenation and kidney protection.

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Journal
Journal of Intensive Care
Published
2025-10-30
DOI
https://doi.org/10.1186/s40560-025-00831-w
Primary Topic
Respiratory Support and Mechanisms
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article
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article

PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study

Louis-Marie Galerneau, Hervé Quintard, Camille Foucault, Michel Pascal et al.
Journal of Intensive Care
Respiratory Support and Mechanisms
article

PEEP-AKI-COVID ICU: Effect of positive end-expiratory pressure on acute kidney injury development in patients with COVID-19-associated acute respiratory distress syndrome: an ancillary analysis of the COVID-ICU study

Louis-Marie Galerneau, Hervé Quintard, Camille Foucault, Michel Pascal, Romain Persichini, Pierre Bouzat, Hervé Outin, Pierre Lemarié, Simon Poignant, Cyril Charron, Olivier Cointault, Jacques Duranteau, Gurvan Le Bouar, Anne Sophie Le Floch, Laurent Argaud, Chloé Achino, Amélie Seguin, Clarisse Blayau, Barbara Darjent, Julien Guntz, Audrey Jacquot, Severine Perez, Damien Vimpère, Gauthier Bionz, Gaël Piton, Pierre-Jean Bertrand, Ludivine Chalumeau Lemoine, Marc Danguy des Déserts, Rabih Hage, M. Durand, Jules Fatséas, Patrick Biston, Sarah Benhamida, Hélène Nougue, Anna Lamacz, Corinne Vézinet, Florent Poirson, Brice Lortat‐Jacob, Patrick Avargues, Maxime Coutrot, Leon Rusel, Gwendoline Rager, Nicole Massou, Grégoire Trebbia, Béatrice La Combe, François Dhelft, Bernard Lanaspre, Lionel Tchatat Wangueu, Anne Chrisment, Marine Lecore, Anatole Harrois, Pierre‐Julien Cungi, Damien Contou, Sophie Jacquier, Pierre Pernet, Stéphan Ehrmann, Bruno Bouchet, David Schnell, Lisa Carenco, Marie-Ange Brou, Alexy Tran‐Dinh, Arnaud Galbois, Raphaël Lepecq, Tomas Urbina, Frank Chemouni, Stella Marchetta, Justine Bonnet-Chateau, Tobias Gauss, Anna Bourreau, Arnaud Sément, François Bouniol, Sophie Hamada, Pierre-Marie Fayolle, Mickaël Landais, Emmanuel Vivier, Francesca De Santi, Matthieu Petit, Wilfried Pujol, Marie-Aline Robaux, Isabelle Etienney, Nicolas Deye, Julien Huntzinger, Jessica Palmyre, Matthieu Mattei, Sonia Garrigou, Jonathan Paillot, Michel Benhamou, Gabriel Parzy, Saïd Lebbah, Richard Descamps, Laetitia Bodénes, Edris Omar, Caroline Rivera, Maxime Leclerc, Florian Prevost, Xavier Stihle, Radu Anghel, Anthony Le Meur, Steve Primmaz, Alexis Ferré, Emmanuel Pardo, Ėlodie Baron, Annabelle Stoclin, Guillaume Lacave, Agathe Delbove, Nathanaël Charrier, Lionel Lamhaut, Maya Perrou, Tristan Morichau-Beauchant, Younes Kerroumi, Jennifer Brunet, Yves Cohen, Ruiying Shi, Claude Sumian, Julien Saison, Anaïs Pitta, Laure Flurin, Ahmed Pasem, Audrey Tientcheu, Tessa Mazard, Maxime Léger, Grégory Fleury, Léa Satre-Buisson, Nicolas Terzi, Thomas Laterrade, Elisabeth Coupez, Audrey Quenet, Olivier Lesieur, Marc Garnier, Michel Boudinaud, Marie‐Béatrice Nogier, Djlali Elaroussi, Christophe Le Terrier, Camille Vinclair, Cécile Saladin, Abolfazl Mohebbi Amoli, Lucie Vettoretti, Patrick Chillet, Benjamin Madeux, Richard Gallot, Virginie Poupinel, Mathieu Page, Benoît Painvin, Christophe Girault, Nicolas Herzog, Jean Dellamonica, Pierre Asfar, Isabelle Desmeules, Anne-Laure Bouilland, Johann Auchabie, Natacha Maquigneau, Michaël Piagnerelli, Sigismond Lasocki, Charlotte Quentin, Pierre-Yves Macq, Lucie Houdou, Christian Richard, Caroline Bornstain, Noémie Suh, Pierre Esnault, Cédric Daubin, Isabelle Geneau, Cédric Darreau, Juliette Chommeloux, Rolland Smonig, Auguste Dargent, Sophie Guilmin‐Crépon, Olivier Andremont, Claudia Casella, Jade Violleau, Benoît Veber, Pierre Garçon, Céline Grégoire, Quentin Maestraggi, Sandrine Mons, Marie-Hélène Hausermann, Sophie Demeret, Anne Jallot, Cécile Aubron, Wulfran Bougouin, Jean-Baptiste Putegnat, Quentin Delforge, Nicolas Barbarot, Clémence Marois, Laurent Jadot, Anne Héron, Hadrien Winiszewski, Pauline Cailliez, Julie Noublanche, Rémi Coudroy, Abdel Ouchike, Sébastien Gibot, Eve Marie Maiziere, Marie-Catherine Besse, Camille Jung, Isabel Roca-Cerezo, Sébastian Voicu, Antoine Monsel, Bruno Gonçalves, Emmanuel Couadau, Aurélie Joret, Stanislas Faguer, Marie Conrad, Pierre Moine, Jérôme Devaquet, Vincent Castelain, Frédérique Bayle, Lyes Knani, Matthieu Jeannot, Aude Sylvestre, Carole Schwebel, Jean-Étienne Herbrecht, Candice Fontaine, Thibaut Baudic, Pascal Hazera, Bertrand P. Delaborde, Thi My Hue Nguyen-Valat, Lucile Marsac, Arnaud Causeret, Arthur Pavot, Emmanuel Canet, Angélie Gentilhomme, Paul Jaubert, Mathieu Bobet, Sébastien Hinard, Alexandre Avenel, Nicolas Mongardon, Geofroy Hariri, Kevin Chaulier, Quentin de Roux, Anne-Charlotte Savida, Mélanie Saint Jouan, Guillaume Dubreuil, Imen Rahmani, Claire Dupuis, Amélie Rollé, Déborah Boyer, Mai-Ahn Nay, Frédéric Pène, Aïssa Kherchache, Sylvain Pignal, Xavier Repessé, Deborah Schenesse, Antoine Kimmoun, Alexandra Lavalard, Bertrand Sauneuf, Pierre Trouiler, Dabor Résière, François Thouy, Tarek Sharshar, Nathalie Abbosh, David Hajage, Lucie Guillemet, Sébastien Jochmans, Vincent Bruckert, Marie-France Bajolet, Christophe Giacardi, Marie Werner, Nicolas Weiss, François Dépret, Juliette Courtiade Mahler, Florence Tubach, Malo Emery, Riad Chelha, Bruno Mégarbane, Bérengère Vivet, Frédérique Schortgen, Baptiste Michard, Djillali Annane, Thomas Baudry, Thomas Caulier, Jean‐Marc Tadié, Jérôme Pugin, Aurélien Frerou, Michel Carlès, Romaric Grenot, Laura Müller, Agathe Selves, Tài Pham, Jean-Claude Lachérade, Benjamin Sztrymf, Cécile Lory, Khaldoun Kuteifan, Alexandre Ouali, Florian Michelin, P. Abraham, Rose-Marie Blot, Younès Benzidi, Soizic Gergaud, Julien Cady, Céline Monard, Sébastien Tanaka, Jérôme Pillot, Cindérella Noël, Vivien Hong Tuan Ha, Juliane Sen, Jean-Pierre Deyme, Thibault Dekeyser, Liliane Charrrier, Jean‐Pierre Frat, Thierry Lazard, Marie-Christine Hérault, Mohamed Dlala, Hafid Ait‐Oufella, Guillaume Géri, Fabienne Boiste, Nicolas Roucaud, Laurence Lavayssière, Cyril Cadoz, Élise Yvin, Nicolas Donat, Florence Daviet, Philippe Montravers, Yanis Kouchit, Nicolas Robin, Christian Roth, Valentin Pointurier, Gaël Bourdin, Otto Hartman, Tahar Saghi, Matthieu Jamme, Laurent Serpin, Marc Vinclair, Quentin Blanc, Romain Lombardi, Jean-Lou Setti, Mathieu Jozwiak, Marie Cantier, Romain Thouny, Chloé Thill, Julie Garcia, Frédéric Martino, Stéphane Rouleau, Quentin Mathais, Jermy Castanera, Déborah Benchetrit, Clémence Marcault, Pierre-Henri Moury, Adrien Bouglé, Étienne Gayat, Guillaume Leloup, Pierre-Yves Egreteau, Charlotte Garret, Thomas Rimmelé, Bernard Lambermont, Pierre-Alexandre Roger, Florent Gobert, Thibault Chapelle, Kais Mhamdi, Sandie Mazerand, François Legay, Jean‐François Payen, Olivier Pajot, Guilhem Courte, Anaïs Dartevel, Sébastien Préau, Charles Damoisel, Aurélien Mazeraud, Alain Combes, Franklin Bruna, Jean-Denis Moyer, Michaël Darmon, Guillaume Voiriot, Marjolaine Cottrel, Jean‐Daniel Chiche, Rémi Paulet, Amandine Bruneau, Mathieu Baldacini, Sébastien Pili Floury, Cécile Zylberfajn, Benjamin Rohaut, Laurent Poirot, Gwenhaël Colin, Florent Montini, Marie‐Amélie Ordan, Bassem Beilouny, Élie Azoulay, Sébastien Gette, Stéphane Dauger, Marion Teulier, Bertrand Delord, Philippe Gouin, Christophe Vinsonneau, Xavier Monnet, Laurent Bitker, François Beloncle, Julien Calus, Grâce Kisoka, Anne Godiér, Brice Rey, Amina Chaalal, Anthony Collin, Christophe Gutton, Nicolas Chudeau, Guillaume Tachon, Catherine Paugam Burtz, Fabienne Plouvier, David Tran-Van, Keyvan Razazi, Benjamin Glenn Chousterman, Alexandre Mebazaa, Sylvène Rosseli, Damien Roux, Elsa Demarest, Valérie Gissot, Mathilde Filippelli, Aymeric Lancelot, Luana Giovannangeli, Christelle Bigot, Vanessa Jean-Michel, Michael Levy, Guillaume Carteaux, Louise-Marie Jandeaux, A. Garin, Christophe Guitton, Stéphane Gaudry, Jean Reignier, Mathieu Sèrié, Gilles Capellier, Messabi Boukhanza, Damien du Cheyron, Emmanuel Weiss, Sarah Valette, Philippe Karoubi, Cédric Bruel, Thibaud Soumagne, Erwen L’Her, Samuel Degoul, Jean-Baptiste Roudau, Nicoletta Bergero, Charlotte Salmon Gandonnière, Christian Lamer, Nica Alexandru, Christophe Cracco, Vincent Gevrey, Thierry Mazzoni, Julien Demiselle, Clémentine Cholet, Florin Berteau, Jean‐Pierre Quenot, Mathieu Guilbart, Charles de Roquetaillade, Abdlazize Sahraoui, Mathilde Neuville, Marie Bouteloup, Pierre Du Pasquier, Marie‐Charlotte Delignette, Antoine Vieillard‐Baron, Arnaud Wilfrid Thille, Benoït Her, Rostane Gaci, Emmanuelle Schaack, Claire Chaignat, Lucie Hierle, Jan Hayon, Julien Textoris, Eddy Lebas, Philippe Feuchere, Jean-Mathias Liteaudon, Yannick Fédun, Marc Amouretti, Meriam Lamraoui, Santiago Freita-Ramos, Christian Pommier, Sylvie Goutte, Isabelle Malissin, Ghyslaine Thao, Thibaut Noël, Fabienne Tamion, Marine Bereiziat, Daniel Zafmahazo, Pierre Gofn, Daniel Mathieu, Nicolas Dufour, Philippe Petua, Hugues Georges, Charlotte Roy, Caroline Gauthier, Matthieu Daniel, Nicolas Bonnet, Delphine Roux, Claire Alessandri, Suela Demiri, Muriel Fartoukh, Armelle Mathonnet, Clément Saccheri, Gabriel Lejour, Martin Dres, Serge Carreira, Matthieu Schmidt, Nicolas de Prost, Joy Mootien, Julien Mayaux, Maïté Chaussard, Claire Pichereau, Alain Mercat, Jonathan Chelly, Antoine Marchalot, Guillaune Louis, Jean‐Michel Constantin, Caroline Hauw‐Berlemont, Frédéric Aubrun, Bruno Lévy, Gaëtan Plantefève, Charles Edouard Luyt, Antoine Gros, Alexandra Beurton, Armand Mekontso‐Dessap, Emmanuel Guérot, Diane Zlotnik, Pascal Andreu, Nesrine Sma, Ramin Ravan, Saad Nseir, Pierre‐Gildas Guitard, Sylvie Ricôme, Fabrice Bruneel, Henri Faure, Jean‐Luc Diehl, Pascal Beuret, Florent Bavozet, Anne-Lyse Masse, Maeva Rodriguez, Sami Hraiech, Nicolas Ferrière, Nicolas Péron, Arthur Vincent, Isabelle Runge, Aurélie Cravoisy, Arnaud De La Chapelle, Michel Ramakers, Mehran Monchi, Martial Thyrault, Mona Assef, Loïc Dopeux, Nolwenn Lucas, Mickaël Cardinale, Matthieu Débarre, Nathan Ebstein, Diane Lena, Jean‐Damien Ricard, Alexandre Demoule, Gaël Pradel, Ly Van Vong, Nicholas Heming, Anne Joosten, Pierre Fillâtre, Dorothée Carpentier, Hervé Mentec, Julien Poissy, Amr Ibrahim, Emmanuelle Bégot, Clément Hofmann, Stéphane Thierry, Marie Labruyère, Isaure Breteau
article en

Abstract

In patients with COVID-19-related ARDS patients, higher PEEP levels within the first 5 days after intubation were independently associated with AKI. These findings underscore the importance of ventilatory strategies to balance oxygenation and kidney protection.

Journal of Intensive CareVol. 13(1)
Université de Tours (FR), Inserm (FR), Université de Versailles Saint-Quentin-en-Yvelines (FR), Université Paris-Saclay (FR), Sorbonne Université (FR), Centre Hospitalier Universitaire de Tours (FR), Assistance Publique – Hôpitaux de Paris (FR), Centre de recherche en Epidémiologie et Santé des Populations (FR), Pitié-Salpêtrière Hospital (FR), Hôpital Ambroise-Paré (FR), Centre Hospitalier Victor Dupouy (FR), Université de Rouen Normandie (FR)
Openalex Percentile: Top 55%
Respiratory Support and Mechanisms
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