Cigarette Smoke Extract and Nicotine Evoke Similar Interoceptive Effects in a Pavlovian Occasion Setting Task in Male and Female Sprague–Dawley Rats
Nicotine has long been used as a proxy for tobacco in non-human animal studies. However, there has always been an undercurrent regarding the appropriateness of this approach given the myriad constituents in tobacco. Though generalization to other behavioural preparations must be done with extreme caution, the current findings suggest that, at least in some capacity, there is overlap in the stimulus characteristics of nicotine and CSE.
Authors
- Jude A. Frie
- Jibran Y. Khokhar (ORCID: https://orcid.org/0000-0002-2169-2275)
- Jennifer E. Murray (ORCID: https://orcid.org/0000-0002-8992-7317)
- Rick A. Bevins (ORCID: https://orcid.org/0000-0002-2438-2264)
- Jessica M. Karlovcec
- Alison Cameron (ORCID: https://orcid.org/0000-0001-9713-3229)
- Davin R Peart (ORCID: https://orcid.org/0000-0002-8737-8967)
- Anita Sikic
- Mckenna A Williams
- Brandon W Florek
Institutions
- University of Nebraska–Lincoln (US)
- Western University (CA)
- University of Guelph (CA)
Publication Details
- Journal
- Nicotine & Tobacco Research
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1093/ntr/ntaf219
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00