The stereoselective pharmacokinetics of bupivacaine after racemate, and the effects of high-fat diet and sex in Sprague–Dawley rats
Bupivacaine exhibits modest stereoselectivity in rats, with diet and sex influencing CL. The application of Bayesian forecasting in sparse sampling models in rats proved to be a robust tool for pharmacokinetic assessment, aligning with the goals of reducing numbers, refining experimental design and replacing invasiveness of procedures in the use of animals.
Authors
- John R. Ussher (ORCID: https://orcid.org/0000-0001-9574-5707)
- Neal M. Davies (ORCID: https://orcid.org/0000-0002-7050-1471)
- Dion R. Brocks (ORCID: https://orcid.org/0000-0001-5024-2268)
- Shamima Parvin
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1093/jpp/rgaf089
- Citations
- 1
- Primary Topic
- Veterinary Pharmacology and Anesthesia
- Type
- article
- Field-Weighted Citation Impact
- 2.35