Investigation of the mechanism by which sigma-1 receptor protein mediates the IRE1-XBP-1s pathway to alleviate cerebral ischemia–reperfusion injury
PTZ activates sigma-1R to regulate the IRE1-XBP-1s pathway which inhibits endoplasmic reticulum stress and apoptosis thereby alleviating cerebral ischemia-reperfusion injury.
Authors
- Yongqi Dong (ORCID: https://orcid.org/0000-0001-9945-5037)
- Lin Ding (ORCID: https://orcid.org/0000-0002-0265-9613)
- Wei Feng (ORCID: https://orcid.org/0000-0002-8304-2737)
- Sheng Fang (ORCID: https://orcid.org/0000-0002-1917-3281)
- Youzhuang Zhu (ORCID: https://orcid.org/0000-0003-2039-4169)
- Jia Liu (ORCID: https://orcid.org/0000-0001-7910-1709)
- Zekun Wang (ORCID: https://orcid.org/0000-0003-0533-4184)
- Qin Zhao
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s40001-025-03246-3
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao University