Establishment of a medial arterial calcification model in C57BL/6J mice via arterial intimal injury
This study not only establishes a MAC animal model by inducing injury to the CCA combined with a VD<sub>3</sub> diet but also introduces a corresponding pathological scoring system. Together, this model, coupled with this associated grading method, provides a valuable toolset for future basic medical research, drug screening, and investigations into the genetic mechanisms of MAC.
Authors
- Ming‐Hui Zhao (ORCID: https://orcid.org/0000-0003-3340-3108)
- Chen Zhang (ORCID: https://orcid.org/0000-0002-5372-1069)
- T. He (ORCID: https://orcid.org/0000-0001-8030-1679)
- Yunhong Zhang (ORCID: https://orcid.org/0000-0002-2899-5068)
- Yan Wang (ORCID: https://orcid.org/0000-0002-4437-7788)
- Hu Chen (ORCID: https://orcid.org/0000-0001-5472-7158)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-8616-9733)
- Guangming Chen (ORCID: https://orcid.org/0000-0002-5353-2655)
- Mingzhe Shao (ORCID: https://orcid.org/0000-0003-3147-6952)
Institutions
- Shanghai Jiao Tong University (CN)
- Shandong Provincial Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diagnosis and Therapy
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/cdt-2025-435
- Citations
- 1
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.43