“Not-So-Indolent” neuroendocrine neoplasms: two case reports of gastrointestinal small cell neuroendocrine carcinomas
These cases emphasize the necessity for heightened clinical suspicion of SCNEC in rapidly progressive GI malignancies, even in atypical presentations. Early recognition and multidisciplinary management are crucial, although current therapeutic options offer limited durability. By delineating site-specific clinical courses, this report contributes to the limited body of evidence on GI-SCNECs and underscores the urgent need for standardized diagnostic criteria and treatment protocols to improve outcomes.
Authors
- David Farnell (ORCID: https://orcid.org/0000-0001-8589-4354)
- Anahita Sanaei Dashti (ORCID: https://orcid.org/0000-0002-2827-3575)
- Andrew Fetz
- Sarvee Moosavi (ORCID: https://orcid.org/0000-0001-7960-6555)
- Jenny E. Chu (ORCID: https://orcid.org/0000-0002-1841-3175)
- Hyun Jae Kim (ORCID: https://orcid.org/0000-0002-3508-9856)
- David F. Schaeffer (ORCID: https://orcid.org/0000-0002-7341-1308)
- Seng Ian Gan
Institutions
- University of British Columbia (CA)
- Vancouver General Hospital (CA)
Publication Details
- Journal
- AME Case Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/acr-2025-71
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00