Metabolic engineering of Streptomyces explomaris for increased production of the reverse antibiotic nybomycin
This study demonstrates the potential of S. explomaris as a chassis for high-level heterologous nybomycin production and its compatibility with renewable marine feedstocks. Regulatory and metabolic engineering effectively relieved key bottlenecks and improved precursor supply. The use of seaweed hydrolysates supports the development of sustainable nybomycin production. Collectively, these findings provide a valuable foundation for future efforts toward improved supply and clinical development of nybomycin.
Authors
- Andriy Luzhetskyy (ORCID: https://orcid.org/0000-0001-6497-0047)
- Jörn Kalinowski (ORCID: https://orcid.org/0000-0002-9052-1998)
- Julian Stegmüller
- Oleksandr Gromyko (ORCID: https://orcid.org/0000-0002-8107-0128)
- Christian Rückert (ORCID: https://orcid.org/0000-0002-9722-4435)
- Yuriy Rebets (ORCID: https://orcid.org/0000-0001-5071-8430)
- Christoph Wittmann (ORCID: https://orcid.org/0000-0002-7952-985X)
- Shu Wei (ORCID: https://orcid.org/0000-0002-8803-9625)
- Marta Rodriguez-Estevez
Institutions
- Lviv University (UA)
- Bielefeld University (DE)
- Saarland University (DE)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s12934-025-02860-4
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Deutsche Forschungsgemeinschaft
- Universität des Saarlandes