A General Synthesis Strategy for Alkali Metal Halide Nanosalts

Nanosalts demonstrate enormous application prospects due to their unique combination of "inorganic salt" and "nano" properties, and their rapid development inevitably requires a rich toolbox of synthesis strategies and materials library. Herein, a general synthesis strategy for the construction of alkali metal halide (AMH) nanosalts is developed, demonstrating generalization and the high degree of plasticity in the multidimensional parameter space. The results of the rational exploration verified that the basicity of the reaction system was important in regulating the growth of nanosalts, while prolonged retention at high temperatures tended to ripen the particles unnecessarily or even lose morphology in the reaction system. The established synthesis procedure was successfully generalized and guided the synthesis of almost all AMH nanosalts. As a proof of concept, nanosalts exhibit qualities in biomedicine that are not found in bulk inorganic salts. This work not only establishes a general approach toward moving from bulk inorganic salts to nanosalts but also provides an innovative perspective to explore the unique potential of classical inorganic salts at the nanoscale.