Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis
Our findings reveal a distinct transdiagnostic phenotype in EP characterized by cognitive inflexibility and arousal dysregulation that is associated with altered integration between sensory, default mode, and subcortical networks. This work suggests that specific patterns of network-level FC may relate to symptom dimensions that cut across conventional diagnostic boundaries, potentially informing more targeted therapeutic approaches.
Authors
- Jason S. Nomi (ORCID: https://orcid.org/0000-0001-7129-3793)
- Haley R Wang (ORCID: https://orcid.org/0000-0002-8042-8343)
- Katherine H. Karlsgodt (ORCID: https://orcid.org/0000-0003-3332-4231)
- Carrie E. Bearden (ORCID: https://orcid.org/0000-0002-8516-923X)
- Charles Schleifer (ORCID: https://orcid.org/0000-0001-8411-0968)
- Bratislav Mišić (ORCID: https://orcid.org/0000-0003-0307-2862)
- Zhen-Qi Liu (ORCID: https://orcid.org/0000-0003-0917-7905)
- Lucina Q. Uddin (ORCID: https://orcid.org/0000-0003-2278-8962)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- University of California, Los Angeles (US)
- Neurobehavioral Systems (US)
- McGill University (CA)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.biopsych.2025.10.024
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00