Enhanced cargo of plasma alpha B crystallin in oligodendrocyte-derived exosomes accompanied by elevated expression of inflammatory factors in the temporal cortex of patients with refractory epilepsy
The finding that plasma oligodendrocyte-derived exosomal CRYAB is upregulated in patients with epilepsy highlights a potential role of oligodendrocyte-secreted CRYAB in its pathogenesis.
Authors
- Nan Zhou (ORCID: https://orcid.org/0000-0001-5541-9421)
- Dongyan Wu
- Zengxin Qi (ORCID: https://orcid.org/0000-0001-5206-9948)
- Xiaoshuai Ji (ORCID: https://orcid.org/0000-0003-1512-6477)
- Ming Chen (ORCID: https://orcid.org/0000-0002-9677-1699)
- Yongsheng Xie (ORCID: https://orcid.org/0009-0005-8983-7169)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1016/j.bbadis.2025.168096
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00