Predictive diagnostic models for newly diagnosed diabetes mellitus in moderate to severe COVID-19: the role of TyG Index, BMI, and inflammatory markers
In our study population, IR rather than insulin deficiency was more strongly associated with newly diagnosed DM in patients with COVID-19. The TyG index may serve as a practical diagnostic marker for predicting newly diagnosed DM in resource-limited settings, with BMI and inflammatory markers further improving model accuracy. However, given our predominantly Black African study population, validation in larger and more diverse populations is needed.
Authors
- Aletta M. E. Millen (ORCID: https://orcid.org/0000-0002-4831-7336)
- Frederick Johan Raal (ORCID: https://orcid.org/0000-0002-9170-7938)
- Bezalem Eshetu Yirdaw (ORCID: https://orcid.org/0000-0001-5673-8037)
- Ismail Kalla (ORCID: https://orcid.org/0000-0001-9131-7123)
- Sulè Gunter (ORCID: https://orcid.org/0000-0002-1711-5934)
- Farzahna Mohamed (ORCID: https://orcid.org/0000-0001-5602-3621)
Institutions
- Bond University (AU)
- University of South Africa (ZA)
- University of the Witwatersrand (ZA)
- Johannesburg Hospital (ZA)
Publication Details
- Journal
- BMC Endocrine Disorders
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s12902-025-02056-2
- Citations
- 1
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- L'Oreal USA
- National Research Foundation
- South African Medical Research Council
- Medical Research Council