Cellular senescence links severe Leptospira infection to chronic kidney disease progression
Severe Leptospira infection drives maladaptive kidney repair through senescence and fibrosis, promoting CKD progression. Targeting cellular senescence may represent a promising strategy to prevent chronic renal damage after leptospirosis.
Authors
- Ya-Chung Tian
- Li‐Fang Chou (ORCID: https://orcid.org/0000-0002-0189-1699)
- Chien Li (ORCID: https://orcid.org/0000-0001-5374-5135)
- Ming‐Yang Chang (ORCID: https://orcid.org/0000-0001-8899-0376)
- Shen‐Hsing Hsu (ORCID: https://orcid.org/0000-0003-3527-4151)
- Huang‐Yu Yang (ORCID: https://orcid.org/0000-0001-6826-9717)
- Chih‐Wei Yang (ORCID: https://orcid.org/0000-0001-9282-811X)
- Yi‐Chun Liu (ORCID: https://orcid.org/0000-0002-0988-5226)
Institutions
- Chang Gung Memorial Hospital (TW)
- Taoyuan Chang Gung Memorial Hospital (TW)
- Linkou Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1016/j.lfs.2025.124057
- Primary Topic
- Leptospirosis research and findings
- Type
- article
- Field-Weighted Citation Impact
- 0.00