Genetically reduced MTHFR activity confers protection against multiple sclerosis
These results support a novel biological hypothesis linking impaired MTHFR function to protection from MS. Further research is needed to elucidate the underlying mechanism and explore potential therapeutic implications.
Authors
- John V. Pluvinage (ORCID: https://orcid.org/0000-0002-9607-2783)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Iyas Daghlas (ORCID: https://orcid.org/0000-0001-6924-0641)
Institutions
- University of California, San Francisco (US)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Neuroimmunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1016/j.jneuroim.2025.578784
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00