Taurodeoxycholic, taurocholic, and glycocholic acids promote hepatic gluconeogenesis via TGR5 in dairy cows
TDCA, TCA, and GCA are key metabolites promoting hepatic gluconeogenesis in dairy cows, with TGR5 as the pivotal receptor and the cAMP/PKA/CREB pathway as the critical downstream mechanism.
Authors
- Yining Zheng
- Jianguo Wang (ORCID: https://orcid.org/0000-0002-6521-200X)
- Lu Deng (ORCID: https://orcid.org/0000-0002-3744-4102)
- Shengrong Lou (ORCID: https://orcid.org/0000-0001-6059-2149)
- R. Zhang
- Lei Chen (ORCID: https://orcid.org/0000-0003-4863-4363)
- Dingping Feng
- Miaomiao Zhu (ORCID: https://orcid.org/0000-0002-2179-0254)
- Junhu Yao (ORCID: https://orcid.org/0000-0002-0848-8392)
- Xinjian Lei
Institutions
- Shenzhen University (CN)
- North West Agriculture and Forestry University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s40104-025-01275-w
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- Natural Science Basic Research Program of Shaanxi Province