Mutations in gyrA and gyrB among drug-resistant Mycobacterium tuberculosis isolates in South Korea
This study confirms gyrA mutations, especially D94G, as primary determinants of FLQ resistance in drug-resistant TB (including MDR-TB) in South Korea. gyrB mutations may also influence resistance. Combining gDST with phenotypic methods may improve resistance profiling.
Authors
- Gyeong In Lee
- Mi-so Kim
- Cheon-Tae Kim
- Shin‐Wook Kang (ORCID: https://orcid.org/0000-0002-5677-4756)
- Kwang-Hyuk Seok (ORCID: https://orcid.org/0000-0003-3195-8775)
- Gicheon Bae
- Ocung Guido (ORCID: https://orcid.org/0000-0002-8021-1398)
- Seonmi Shin
- Seung‐Heon Lee (ORCID: https://orcid.org/0000-0002-0578-7653)
- Jeongmin Song (ORCID: https://orcid.org/0000-0002-6777-3505)
- Hwi Jun Kim (ORCID: https://orcid.org/0000-0001-7007-8442)
- Soul-hee Kim
- Di Han (ORCID: https://orcid.org/0000-0001-9531-0375)
- Arim Song
- Eunseon Kim (ORCID: https://orcid.org/0000-0002-1060-2254)
- Orena Beatrice
- Ryeun Heo
- Mary Akumu
- Hye-Jin Kim
- Hyeon-Ju Lee (ORCID: https://orcid.org/0009-0004-8485-5467)
- Hee Joo Lee (ORCID: https://orcid.org/0000-0002-5527-7125)
- Seungmo Kim (ORCID: https://orcid.org/0000-0001-5182-8383)
- Juliet N. Babirye (ORCID: https://orcid.org/0000-0002-6665-2920)
- Heejin Kim (ORCID: https://orcid.org/0000-0002-6815-2313)
- Hyeon-Su Kim (ORCID: https://orcid.org/0009-0000-5399-4545)
- Jeong-hui Gwon
Institutions
- Laboratoire National de Référence (MA)
- Korea National Tuberculosis Association (KR)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1016/j.meegid.2025.105849
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40