Intra-articular delivery of allogeneic bone marrow derived mesenchymal stromal cells (BM-MSCs) for painful lumbar facet arthropathy: a phase I clinical trial
This study demonstrated a favorable safety profile for intra-articular delivery of BM-MSCs for painful LFA. Preliminary therapeutic benefits were observed, including back pain relief, improved physical function, and reduced facet joint degeneration. Further larger, randomized clinical trials are warranted to further assess its safety and efficacy. Trial Registration ClinicalTrials.gov Identifier: NCT04410731.
Authors
- Erica Engelberg-Cook (ORCID: https://orcid.org/0000-0003-4186-9063)
- Vance T. Lehman (ORCID: https://orcid.org/0000-0002-8713-8293)
- Jeffrey A. Stone (ORCID: https://orcid.org/0000-0002-8417-0431)
- Abba C. Zubair (ORCID: https://orcid.org/0000-0003-4827-4740)
- Elani F. Wiest (ORCID: https://orcid.org/0000-0002-8819-3171)
- Nisha Durand (ORCID: https://orcid.org/0000-0002-4143-4230)
- Michael D. Osborne (ORCID: https://orcid.org/0000-0003-3642-3737)
- Wenchun Qu (ORCID: https://orcid.org/0000-0003-2402-8318)
- Sahil Gupta (ORCID: https://orcid.org/0000-0003-3221-8752)
- Dan Yan (ORCID: https://orcid.org/0000-0001-7531-5814)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-9368-6149)
- David A. Miller (ORCID: https://orcid.org/0000-0002-0033-6298)
- Alfredo Quiñones-Hinojosa
- Drew M. Witter
- Kathryn A. Siebenaler
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s13287-025-04674-y
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47