Chemical direct conversion of human fibroblasts to mesenchymal stem cells that can alleviate inflammation in vivo
The three compounds successfully converted HDFs into MSC-like cells with high anti-inflammatory activities, which would be useful in regenerative medicine for inflammatory disease.
Authors
- Toshiro Yamamoto (ORCID: https://orcid.org/0000-0001-9797-1556)
- Yoshihiro Sowa (ORCID: https://orcid.org/0000-0001-5531-9009)
- Osam Mazda (ORCID: https://orcid.org/0000-0001-9489-3556)
- Kenta Yamamoto (ORCID: https://orcid.org/0000-0003-0203-8603)
- Tsunao Kishida
- Makoto Seki (ORCID: https://orcid.org/0000-0003-3750-6921)
Institutions
- Nihon University (JP)
- Jichi Medical University (JP)
- Kyoto Prefectural University of Medicine (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1186/s13287-025-04605-x
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science