In silico clinical trial to predict the efficacy of alendronate for preventing hip fractures
The distribution of hip fracture incidence predicted by the model included the clinical data for both groups. This In Silico trial can be applied in the future to improve clinical trial design and drug development, enabling a virtual pathway to the efficacy assessment of bone drugs.
Authors
- Antonino A. La Mattina (ORCID: https://orcid.org/0000-0002-9927-2393)
- Sara Oliviero (ORCID: https://orcid.org/0000-0002-3111-2609)
- Marco Viceconti (ORCID: https://orcid.org/0000-0002-2293-1530)
- Giacomo Savelli (ORCID: https://orcid.org/0009-0004-7492-6436)
Institutions
- Istituto Ortopedico Rizzoli (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Clinical Biomechanics
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.clinbiomech.2025.106689
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00