Short versus long-course antibiotic therapy for pyogenic liver abscess: an emulated target trial
In our study, an antibiotic course of ≤30 days did meet the noninferiority threshold of 10% at 90 days compared with longer durations for relapse-free survival. Noninferiority was also met in the subgroup of drained patients but not in undrained patients.
Authors
- Olivier Roux (ORCID: https://orcid.org/0000-0003-1563-7066)
- Antoine Hamon (ORCID: https://orcid.org/0009-0006-1198-8773)
- A. Lefort (ORCID: https://orcid.org/0000-0002-4507-6426)
- Victoire de Lastours (ORCID: https://orcid.org/0000-0003-1160-2069)
- G. Rossi (ORCID: https://orcid.org/0000-0001-6645-0731)
- Clara Pouchelon
- Safi Dokmak (ORCID: https://orcid.org/0000-0002-7811-2155)
- Maxime Beydon (ORCID: https://orcid.org/0000-0003-4924-093X)
- Aurélien Sokal (ORCID: https://orcid.org/0000-0002-1198-8689)
- B. Fantin (ORCID: https://orcid.org/0000-0001-7904-9402)
- Maxime Ronot (ORCID: https://orcid.org/0000-0001-7464-3939)
- Yann Nguyen (ORCID: https://orcid.org/0000-0002-0866-3824)
- Frédéric Bert
- Virginie Zarrouk
Institutions
- Délégation Paris 5 (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Hôpital Beaujon (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR)
- Centre de Recherche Épidémiologie et Statistique (FR)
Publication Details
- Journal
- Clinical Microbiology and Infection
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1016/j.cmi.2025.10.020
- Citations
- 1
- Primary Topic
- Amoebic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.40