FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway
FGF21 promotes PINK1-mediated mitophagy to attenuate cardiac hypertrophy, and mismatched FGFR1 expression may hamper the beneficial effect of FGF21 on cardiac hypertrophy.
Authors
- Li Zheng (ORCID: https://orcid.org/0000-0001-7335-4609)
- Guohua Gong (ORCID: https://orcid.org/0000-0002-9652-1040)
- Yihan Zheng (ORCID: https://orcid.org/0009-0009-9552-7406)
- Yuan Qin (ORCID: https://orcid.org/0000-0003-0205-5454)
- Bilin Liu (ORCID: https://orcid.org/0000-0002-0701-0741)
- Lei Chen (ORCID: https://orcid.org/0009-0003-4906-5163)
- Mengting Dai
- Xiangyang Tong
Institutions
- Nanjing University of Chinese Medicine (CN)
- Army Medical University (CN)
- Wenzhou Medical University (CN)
- Ministry of Education (KR)
- Southwest Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.jare.2025.10.053
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00