Population pharmacokinetics of cefazolin administered as prophylaxis in paediatric patients undergoing cardiac surgery
Postoperative cefazolin concentrations in paediatric patients undergoing cardiopulmonary bypass are often inadequate to maintain optimal antimicrobial prophylaxis. More frequent postoperative dosing or the use of extended and continuous infusion strategies can ensure effective target attainment, potentially reducing the risk of surgical site infections in this vulnerable population.
Authors
- Prem Venugopal (ORCID: https://orcid.org/0000-0002-0416-7823)
- Brett C McWhinney (ORCID: https://orcid.org/0000-0001-9632-1148)
- Supreet P Marathe (ORCID: https://orcid.org/0000-0002-7793-8705)
- Nelson Alphonso (ORCID: https://orcid.org/0000-0002-3735-8298)
- Jessica Suna (ORCID: https://orcid.org/0000-0003-1415-5532)
- Jacobus Ungerer (ORCID: https://orcid.org/0000-0003-4929-0929)
- Suzanne L. Parker (ORCID: https://orcid.org/0000-0002-6124-7475)
- Xin Liu (ORCID: https://orcid.org/0000-0002-6210-8100)
- Vesa Cheng (ORCID: https://orcid.org/0000-0002-7348-2659)
- Gregory Moloney
Institutions
- Queensland Health (AU)
- The University of Queensland (AU)
- Princess Alexandra Hospital (AU)
- Children’s Health Queensland Hospital and Health Service (AU)
- Children's Health Queensland Hospital and Health Service (AU)
- Central Queensland University (AU)
Publication Details
- Journal
- Anaesthesia Critical Care & Pain Medicine
- Published
- 2025-10-30
- DOI
- https://doi.org/10.1016/j.accpm.2025.101653
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00