An alternative novel total synthesis of relgro

A novel stereoselective approach for synthesising a 10-membered β-resocylic macrolide, relgro (<b>1</b>) was established, utilising known chiral bis-epoxide and commercially made available Orsellinic acid. Key steps included Yamaguchi macrolactonization, hydroboration and alkylation of 1,3-dithiane as key steps.