Integration of scRNA-seq and bulk RNA-seq reveals that macrophage ferroptosis inhibits MSC osteogenic differentiation in inflammatory microenvironments
Inhibiting macrophage ferroptosis promoted the polarization of macrophages towards the M2 phenotype, alleviated MSC PANoptosis, and promoted bone regeneration in the inflammatory microenvironment. This study provides a novel perspective on the pathological mechanisms of bone infections and identifies potential therapeutic targets.
Authors
- Rui Yang (ORCID: https://orcid.org/0000-0002-7281-7672)
- Yudun Qu (ORCID: https://orcid.org/0000-0002-0905-2937)
- Jiabao Liu (ORCID: https://orcid.org/0000-0002-5440-1841)
- Changliang Xia (ORCID: https://orcid.org/0000-0003-4348-2196)
- Yong Qi (ORCID: https://orcid.org/0000-0002-2653-1307)
- Jianping Wen (ORCID: https://orcid.org/0000-0001-5388-5680)
- Shuanji Ou
- Jiaxuan Li (ORCID: https://orcid.org/0000-0002-6146-9780)
- Yang Yang (ORCID: https://orcid.org/0000-0002-1684-7105)
- Changpeng Xu (ORCID: https://orcid.org/0000-0003-0686-5892)
- Wei Zen
Institutions
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1016/j.intimp.2025.115744
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52