Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine
In healthy U.K. adults who were challenged with S. Paratyphi A in a controlled human infection model, a two-dose series of CVD 1902 led to protection against S. Paratyphi A infection without safety concerns. (Funded by the Medical Research Council; VASP ISRCTN Registry number, 15485902.).
Authors
- Rajeka Lazarus (ORCID: https://orcid.org/0000-0002-4683-1331)
- Maheshi Ramasamy (ORCID: https://orcid.org/0000-0002-2119-951X)
- Young Chan Kim (ORCID: https://orcid.org/0000-0003-2847-9407)
- Brian Angus (ORCID: https://orcid.org/0000-0003-3598-7784)
- Naina McCann (ORCID: https://orcid.org/0000-0001-5864-1175)
- Deepashri Rao (ORCID: https://orcid.org/0000-0002-1950-962X)
- Thomas C. Darton (ORCID: https://orcid.org/0000-0003-2209-9956)
- Noshi Maria
- Viswanathan Mohan (ORCID: https://orcid.org/0000-0001-5038-6210)
- Madhulika Naidu
- Andrea M. Collins (ORCID: https://orcid.org/0000-0002-4094-1572)
- Xinxue Liu (ORCID: https://orcid.org/0000-0003-1107-0365)
- Narges Ebrahimi (ORCID: https://orcid.org/0000-0002-8953-6842)
- Katherine R. W. Emary (ORCID: https://orcid.org/0000-0002-0708-6391)
- Grace C. Macaulay (ORCID: https://orcid.org/0000-0003-2641-3359)
- Nisha Singh (ORCID: https://orcid.org/0000-0002-1312-688X)
- Sophie Vernon
- Saul N. Faust (ORCID: https://orcid.org/0000-0003-3410-7642)
- Margarete Paganotti Vicentine
- Amy Flaxman (ORCID: https://orcid.org/0000-0001-6460-1372)
- Christopher Green (ORCID: https://orcid.org/0000-0002-1984-4014)
- C Molina (ORCID: https://orcid.org/0000-0003-3855-0609)
- Andrew J. Pollard
- Myron M. Levine
- Florence McLean
- Melanie Greenland
- Ravindra Paidisetti
Institutions
- University of Maryland, Baltimore (US)
- University Hospitals Birmingham NHS Foundation Trust (GB)
- University of Liverpool (GB)
- Liverpool School of Tropical Medicine (GB)
- Aintree University Hospitals NHS Foundation Trust (GB)
- Churchill Hospital (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- University of Bristol (GB)
- Bharat Biotech (India) (IN)
- Sheffield Teaching Hospitals NHS Foundation Trust (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- Regional Development Agency (CZ)
- Oxford University Hospitals NHS Trust (GB)
- NIHR Wellcome Trust Southampton Clinical Research Facility (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Southampton (GB)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1056/nejmoa2502992
- Citations
- 2
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.32