FEATURES OF HUMORAL IMMUNE RESPONSE IN PATIENTS WITH VARIOUS FORMS OF PERICORONITIS AND CONNECTIVE TISSUE DYSPLASIA

Subject: indicators of the humoral immunity link, systemic and dental dysplastic manifestations. Objectives: to study the indices of the humoral immunity link of patients with various forms of pericoronitis and connective tissue dysplasia (CTD). Methodology. The study involved 327 women who were divided into two groups: with the presence of established connective tissue dysplasia (n = 142) and without it (n = 185). The humoral immunity in the examined women (30 with CTD and chronic pericoronitis, 30 with CTD and acute pericoronitis, 30 without CTD and chronic pericoronitis) was evaluated by determining immunoglobulins, CIC, C3- and C4-components of complement by radical immunodiffusion. Interleukin-6, interleukin-10 of blood plasma were evaluated by enzyme-linked immunosorbent assay. Results. It was found that immunologic changes in chronic pericoronitis against CTD background were manifested by increased concentration of CIC (198.52 ± 5.98, opt. den.), IgG (14.77 ± 1.23, g/l), decreased production of IgA (2.89 ± 0.27, g/l), IL-10 (12.72 ± 0.14, pg/ml) (p < 0.05). In acute pericoronitis against CTD background, the opposite immunologic picture was noted, associated with decreased concentration of serum CIC (123.85 ± 4.12, opt. den.) and decreased production of IgA (1.42 ± 0.05, g/l), IgG (11.87 ± 0.74, g/l), IL-10 (12.88 ± 0.28, pg/ml) (p < 0.05). Analyzing the frequency of early and late complications in acute pericoronitis, lower third molars eruption disorder in the postoperative period in the compared groups, their diversity was found to be greater in the group of the examined with connective tissue dysplasia (jaw alveolitis, jaw periostitis, bleeding (bulbous), phlegmons and abscess of the mouth area). Conclusions. The revealed immunologic abnormalities in the humoral link increase the risk of purulent-septic complications in the group with connective tissue dysplasia.