Neuropathologic Changes in People With Essential Tremor With Dementia
Our neuropathologic description of ET-dementia shows that, in this sample of 40 participants with ET-dementia, Alzheimer pathology is the prime driver of marked cognitive impairment in ET. Further studies are needed to refine our understanding of the nature of tau aggregation in ET and the extent to which this is similar to or diverges from that seen in AD. One implication of the current finding, which is a more direct link between ET and AD, is that this opens the door to blood-based biomarker testing in individuals with ET who are experiencing cognitive difficulties.
Authors
- Nora Hernández (ORCID: https://orcid.org/0000-0001-7038-1492)
- Diane S. Berry (ORCID: https://orcid.org/0000-0003-4867-0663)
- Stephanie Cosentino (ORCID: https://orcid.org/0000-0001-5684-143X)
- Elan D. Louis (ORCID: https://orcid.org/0000-0003-2062-362X)
- Phyllis L. Faust (ORCID: https://orcid.org/0000-0001-6533-7921)
- T. Sloane Guy (ORCID: https://orcid.org/0000-0003-0543-306X)
- Ethan Wainman
Institutions
- NewYork–Presbyterian Hospital (US)
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1212/wnl.0000000000214310
- Citations
- 2
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78