Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores

In this study, the cut-off values for the partial pressure of arterial oxygen to the fraction of inspired oxygen (P/F ratio) were investigated in a large Finnish intensive care database and validated externally with the US intensive care registry. The aim was to support a revision of the cut-off values for the P/F ratio in the Sequential Organ Failure Assessment (SOFA) score. The results showed that incremental changes in the P/F ratio of 10 kPa are better than 13 kPa and emphasize the need for critical assessment of the current SOFA score.

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Publication Details

Journal
Acta Anaesthesiologica Scandinavica
Published
2025-10-29
DOI
https://doi.org/10.1111/aas.70137
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
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article

Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores

Pirkka T. Pekkarinen, Christian Jung, Mervyn Singer, Tuomas A. Selander et al.
Acta Anaesthesiologica Scandinavica
Sepsis Diagnosis and Treatment
article

Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores

Pirkka T. Pekkarinen, Christian Jung, Mervyn Singer, Tuomas A. Selander, Greg S. Martin, Bram Rochwerg, Matti Reinikainen, Cornelius Sendagire, Dipayan Chaudhuri, Rui Paulo Moreno, John G. Laffey, Anssi Pölkki
article en

Abstract

In this study, the cut-off values for the partial pressure of arterial oxygen to the fraction of inspired oxygen (P/F ratio) were investigated in a large Finnish intensive care database and validated externally with the US intensive care registry. The aim was to support a revision of the cut-off values for the P/F ratio in the Sequential Organ Failure Assessment (SOFA) score. The results showed that incremental changes in the P/F ratio of 10 kPa are better than 13 kPa and emphasize the need for critical assessment of the current SOFA score.

Acta Anaesthesiologica ScandinavicaVol. 70(1)
Grady Memorial Hospital (US), University of Helsinki (FI), University of Lisbon (PT), University of Eastern Finland (FI), Ollscoil na Gaillimhe – University of Galway (IE), Helsinki University Hospital (FI), St George’s University Hospitals NHS Foundation Trust (GB), Bury College (GB), University Hospital Galway (IE), Kuopio University Hospital (FI), Impact (CA), Heinrich Heine University Düsseldorf (DE), University College London (GB), St. Joseph’s Healthcare Hamilton (CA), Makerere University (UG), Universidade Nova de Lisboa (PT), McMaster University (CA)
Openalex Percentile: Top 58%
Sepsis Diagnosis and Treatment
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