Enantioselective Suzuki–Miyaura Coupling of Unactivated C–O Electrophiles via Nickel Catalysis

Herein, the first nickel-catalyzed enantioselective Suzuki-Miyaura coupling of unactivated C-O electrophiles is demonstrated and facilitates the preparation of valuable atropisomeric 2-hydroxybiaryls without the demand for highly reactive organometallic reagents. Furthermore, we conduct derivation experiments for the synthesis of diverse privileged chiral catalysts and ligands.