Impact of oxidative stress on female reproductive parameters: an analysis of systemic and follicular biomarkers
Glutathione is a robust and clinically promising redox biomarker for female fertility, evidencing strong correlations between systemic and follicular redox markers. Advancing age and repeated ovarian stimulation were shown to compromise antioxidant capacity, negatively impacting reproductive outcomes. Establishing reference values, particularly for the GSH/GSSG ratio, may enable its use as a prognostic tool, while the quantification of ROS and RNS could support personalized interventions and ovarian stimulation protocols.
Authors
- Daniel C. Moreira (ORCID: https://orcid.org/0000-0003-4082-156X)
- Tathyana Benetis Piau (ORCID: https://orcid.org/0009-0005-2936-2149)
- Guilherme Gomes Carvalho (ORCID: https://orcid.org/0000-0002-9888-8110)
- Marta Amaral (ORCID: https://orcid.org/0000-0001-8006-7309)
- Paulo Eduardo Narcizo de Souza (ORCID: https://orcid.org/0000-0002-4289-8678)
- Fernanda Paulini
- Natalia I. Zavattiero Tierno
- Jair Trapé Goulart (ORCID: https://orcid.org/0000-0003-0737-1077)
- Aline Rodrigues (ORCID: https://orcid.org/0000-0002-3548-4119)
- Fabiane H Veiga
- Hitomi Nakagawa
- Yamara A Macedo
Institutions
- Universidade de Brasília (BR)
- Morpho (United States) (US)
- Institute of Physics (AZ)
- Hospital Universitário de Brasília (BR)
- Center for Human Reproduction (US)
Publication Details
- Journal
- JBRA
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5935/1518-0557.20250047
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Distrito Federal