Prevention of infection in peripheral arterial reconstruction of the lower limb

Prophylactic antibiotics may reduce SSIs in peripheral arterial reconstruction of the lower limb with low-certainty evidence. We found no superiority among specific antibiotics or differences in extended use (over 24 hours) compared with shorter use (up to 24 hours), with low-certainty evidence. Closed incision negative pressure therapy may lower the SSI risk, but this is based on very low-certainty evidence. For other interventions, very low- to moderate-certainty evidence showed little or no significant differences across various outcomes. We advise caution when interpreting these conclusions due to the limited number of events in all groups and comparisons.