Thalamus not basal forebrain is atrophied in non‐demented PSEN1 E280A carriers
Basal forebrain volume preserved in non-demented presenilin-1 (PSEN1) E280A carriers.Hippocampal volume preserved in non-demented PSEN1 E280A carriers.Thalamic atrophy observed in non-demented PSEN1 E280A carriers.No link between amyloid/tau pathology and basal forebrain volume.Tau burden linked to hippocampal and thalamic volume loss.
Authors
- Lusiana Martínez
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- David Fernando Aguillon (ORCID: https://orcid.org/0000-0003-2283-536X)
- Alice Grazia (ORCID: https://orcid.org/0000-0001-8861-3183)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Bing He (ORCID: https://orcid.org/0000-0003-3877-4872)
- Stefan Teipel
Institutions
- Harvard University (US)
- German Center for Neurodegenerative Diseases (DE)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70206
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00