Role of Branched‐Chain Amino Acids in Mitigating Osteosarcopenia: An Experimental Study Using Ovariectomised Mice Models

BCAA supplementation alleviates muscle atrophy and partially preserves bone microarchitecture in OVX mice. Importantly, our data highlight bone-derived sclerostin as a molecular link that transmits bone signals to muscle; BCAA mitigates osteosarcopenia by modulating this bone-to-muscle endocrine axis via Wnt signalling. Although improvements in bone structure were modest, the findings position BCAAs as a promising adjunct therapy targeting the integrated bone-muscle unit.