Platelet Recovery and Its Impact on Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation: A Japanese Nationwide Retrospective Study
In this Japanese registry-based analysis of 9105 adult patients with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation, a marked difference in survival was observed based on platelet levels: ≤ 20 × 10<sup>9</sup>/L, 20-50 × 10<sup>9</sup>/L, and > 50 × 10<sup>9</sup>/L. The number of patients with thrombocytopenia receiving cord blood (CB, 39%) was significantly larger than those receiving unrelated bone marrow (uBM, 17%) on Day 50 (p < 0.001); however, this difference disappeared on Day 100 posttransplantation (both 11%, p = 0.4).
Authors
- Masatsugu Tanaka (ORCID: https://orcid.org/0000-0001-8814-230X)
- Naoyuki Uchida (ORCID: https://orcid.org/0000-0001-5952-5926)
- Kazushi Maruo (ORCID: https://orcid.org/0000-0002-3093-0386)
- Mamiko Sakata‐Yanagimoto (ORCID: https://orcid.org/0000-0001-7310-8045)
- Yuta Hasegawa (ORCID: https://orcid.org/0000-0002-9925-2093)
- Toshihiro Matsukawa (ORCID: https://orcid.org/0000-0003-2371-3778)
- Shinichi Kobayashi (ORCID: https://orcid.org/0000-0002-5600-5826)
- Noboru Asada (ORCID: https://orcid.org/0000-0001-7322-5460)
- Naoki Kurita (ORCID: https://orcid.org/0000-0002-1283-4307)
- Noriko Doki (ORCID: https://orcid.org/0000-0002-8661-3179)
- Nobuhiro Hiramoto (ORCID: https://orcid.org/0000-0002-0472-6680)
- Tetsuya Nishida
- Fumihiko Ishimaru (ORCID: https://orcid.org/0000-0002-7668-6083)
- Hideki Nakasone (ORCID: https://orcid.org/0000-0001-5812-9315)
- Toshiro Kawakita (ORCID: https://orcid.org/0000-0001-9595-9529)
- Shuichi Ota (ORCID: https://orcid.org/0000-0002-3631-244X)
- Junya Kanda (ORCID: https://orcid.org/0000-0002-6704-3633)
- Makoto Onizuka (ORCID: https://orcid.org/0000-0003-3864-0823)
- Fumihiko Kimura (ORCID: https://orcid.org/0000-0001-6223-9904)
- Hirohisa Nakamae (ORCID: https://orcid.org/0000-0003-4203-990X)
- Yachiyo Kuwatsuka (ORCID: https://orcid.org/0000-0001-6092-3948)
- Ken Tabuchi (ORCID: https://orcid.org/0000-0001-7739-8780)
- Takahiro Fukuda
- Masashi Sawa
- Yoshiko Atsuta
Institutions
- Tokai University (JP)
- University of Tsukuba (JP)
- Jichi Medical University (JP)
- Aichi Medical University (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- Japanese Red Cross Society, Japan (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- Nagoya University Hospital (JP)
- Okayama University Hospital (JP)
- Sapporo Hokuyu Hospital (JP)
- Japanese Red Cross Nagoya Daiichi Hospital (JP)
- Hokkaido University Hospital (JP)
- Anjo Kosei Hospital (JP)
- The Japanese Data Center for Hematopoietic Cell Transplantation (JP)
- Kobe City Medical Center General Hospital (JP)
- Kumamoto Medical Center (JP)
- Osaka City University Hospital (JP)
- Jichi Medical University Saitama Medical Center (JP)
- Toranomon Hospital (JP)
- Kanagawa Cancer Center
- Osaka Metropolitan University (JP)
- National Defense Medical College (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- American Journal of Hematology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1002/ajh.70124
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Japan Society for the Promotion of Science