Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study
Our study represents the first CNV analysis of ICH risk. While significant associations between large, rare CNVs and ICH risk were not established, the findings indicate potential pathways for further research. The identified trends warrant further investigation, and our methodological framework provides a foundation for future large-scale studies aimed at elucidating the role of CNVs in ICH pathogenesis and outcomes.
Authors
- Christopher D. Anderson (ORCID: https://orcid.org/0000-0002-0053-2002)
- Daniel Woo (ORCID: https://orcid.org/0000-0002-2466-7155)
- Hyacinth I. Hyacinth (ORCID: https://orcid.org/0000-0002-1991-7463)
- Mary E. Comeau (ORCID: https://orcid.org/0000-0001-7079-8781)
- Savvina Prapiadou (ORCID: https://orcid.org/0000-0001-7415-2566)
- Stacie L Demel (ORCID: https://orcid.org/0000-0002-3000-8420)
- Timothy D. Howard (ORCID: https://orcid.org/0000-0003-2518-4902)
- Caspar Grond‐Ginsbach
- Padmini Sekar (ORCID: https://orcid.org/0000-0002-3734-5075)
- Bowang Chen (ORCID: https://orcid.org/0000-0002-9447-0948)
- Tamara N. Kimball (ORCID: https://orcid.org/0000-0002-1107-0771)
- Carl D. Langefeld
- Jonathan Rosand
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Massachusetts General Hospital (US)
- National Clinical Research Center for Digestive Diseases (CN)
- Jacobs (United States) (US)
- Wake Forest University (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1002/acn3.70230
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- NIH Clinical Center