Phenotype and Long‐Term Outcome in Recurrent Paediatric Acute Liver Failure: Systematic Review and Individual Participant Data Analysis
Most patients with RALF present in the first year of life and have a self-limiting course. Episodes of acute liver failure are often associated with febrile illness. Liver transplantation for RALF remains controversial and may be less appealing in etiologies that tend to resolve with age. We recommend whole-exome sequencing with a targeted search for NBAS, SCYL1, RINT1 and LARS1 for patients presenting with unexplained acute liver failure in the setting of a febrile illness.
Authors
- Blayne Amir Sayed (ORCID: https://orcid.org/0000-0003-3224-8871)
- Robert Bandsma (ORCID: https://orcid.org/0000-0001-6358-4750)
- Harry Sutton
- Vicky L. Ng (ORCID: https://orcid.org/0000-0002-9998-5692)
- Jessie Cunningham (ORCID: https://orcid.org/0000-0002-3453-0515)
- Or Steg Saban (ORCID: https://orcid.org/0000-0001-7281-3949)
Institutions
- Hospital for Sick Children (CA)
Publication Details
- Journal
- Liver International
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1111/liv.70412
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Canadian Association for the Study of the Liver
- Canadian Association of Gastroenterology
- Canadian Institutes of Health Research