Identification and Computational Analysis of BRCA2 Variants in Mexican Women from Jalisco, Mexico, with Breast and Ovarian Cancer
<i>BRCA2</i> variants were found in 12.86% of patients, including six VUSs not reported in other populations. Several affected key functional domains with predicted deleterious effects. Findings support the need for genetic panels tailored to the Mexican population.
Authors
- Asbiel Felipe Garibaldi-Ríos (ORCID: https://orcid.org/0009-0003-9788-1106)
- José Elías García‐Ortíz (ORCID: https://orcid.org/0000-0003-1504-1457)
- Luis E. Figuera (ORCID: https://orcid.org/0000-0002-6096-4579)
- Sandra del Carmen Mendoza‐Ruvalcaba (ORCID: https://orcid.org/0000-0001-6931-8103)
- Blanca Miriam Torres-Mendoza (ORCID: https://orcid.org/0000-0003-2233-571X)
- Martha Patricia Gallegos‐Arreola (ORCID: https://orcid.org/0000-0003-4539-1693)
- María Teresa Magaña‐Torres (ORCID: https://orcid.org/0000-0002-9843-0644)
- Ingrid Patricia Dávalos‐Rodríguez (ORCID: https://orcid.org/0000-0001-7096-919X)
- Janet Valdez
- Guillermo Moisés Zúñiga‐González (ORCID: https://orcid.org/0000-0003-1257-4637)
- Mónica Alejandra Rosales‐Reynoso (ORCID: https://orcid.org/0000-0003-0387-4996)
- Belinda Claudia Gómez‐Meda (ORCID: https://orcid.org/0000-0003-2774-6390)
- César de Jesús Tovar-Jácome (ORCID: https://orcid.org/0009-0009-2866-6633)
- Patricia Montserrat García-Verdín
- Sergio Osvaldo Meza-Chavolla (ORCID: https://orcid.org/0000-0002-0843-7595)
- Raquel Villegas-Pacheco
- René Gómez-Cerda
Institutions
- Mexican Social Security Institute (MX)
- Universidad de Guadalajara (MX)
Publication Details
- Journal
- Medical Sciences
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3390/medsci13040248
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Instituto Mexicano del Seguro Social