Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes
Our findings suggest that advanced paternal age at conception correlates with altered DNA methylation at a small number of loci in the human placenta, notably affecting genes involved in neurodevelopment. This study highlights the use of the placenta DNA methylome as a surrogate marker for the potential impact of advanced paternal age on the child.
Authors
- Sherri Lee Jones (ORCID: https://orcid.org/0000-0003-0511-7198)
- Catherine M. Herba (ORCID: https://orcid.org/0000-0001-7906-4696)
- Josée Martel (ORCID: https://orcid.org/0000-0001-8455-354X)
- Tina Montreuil (ORCID: https://orcid.org/0000-0002-4549-1216)
- Donovan Chan (ORCID: https://orcid.org/0000-0002-6860-8384)
- Jean R. Séguin (ORCID: https://orcid.org/0000-0003-3359-6202)
- William D. Fraser (ORCID: https://orcid.org/0000-0001-9042-2415)
- Jacquetta M. Trasler (ORCID: https://orcid.org/0000-0002-4830-042X)
- Julia Barnwell (ORCID: https://orcid.org/0000-0001-8416-9687)
- Sophia Rahimi
- Sara Abdessamie
- Tuong‐Vi Nguyen
- Celia M. T. Greenwood
Institutions
- Université de Sherbrooke (CA)
- Université du Québec à Montréal (CA)
- Douglas College (CA)
- University of Toronto (CA)
- McGill University Health Centre (CA)
- Jewish General Hospital (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Andrology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1111/andr.70131
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université Laval
- University of Ottawa
- McGill University
- Université de Sherbrooke
- McGill University Health Centre
- University of Toronto
- Université de Montréal
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé