Olanzapine-induced metabolic syndrome is partially mediated by oxytocinergic system dysfunction in female Sprague-Dawley rats
OLZ-induced metabolic abnormalities were mitigated by oxytocin, indicating that the oxytocinergic system hypofunction may be implicated in its pathophysiology. These results highlight OT's therapeutic potential and call for further clinical research to explore its role in the management of antipsychotic-induced metabolic syndrome.
Authors
- Peter W. Mwangi (ORCID: https://orcid.org/0000-0002-9019-5969)
- Boniface M. Chege (ORCID: https://orcid.org/0000-0001-8892-3552)
- Frederick Bukachi
- Elsie D. Oduor
- Sharon F. Olago
Institutions
- University of Nairobi (KE)
- Dedan Kimathi University of Technology (KE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1371/journal.pone.0334966
- Primary Topic
- Neuroendocrine regulation and behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00