Baseline task performance predicts mini-mental state examination improvement after individuals with dementia practice an N-back task with bilateral transcranial direct current stimulation

This study replicates a pervasive finding in the tDCS literature: participants who perform worse at baseline often demonstrate the greatest improvements with tDCS. Furthermore, these results have clinical implications, in that tDCS may be most beneficial in individuals when clear deficits or impairments are present. Attempts to treat less severe participants might fail to show improvement with tDCS. Ultimately, baseline condition should be routinely considered when evaluating tDCS results.